ACE-167

ACE-167 is a research peptide derived from the voltage-dependent anion channel 1 (VDAC1), primarily involved in studies related to mitochondrial cholesterol transport. It functions by modulating the interaction between VDAC1 and cholesterol within the mitochondrial membrane, affecting cellular energy metabolism and endocrine biosynthesis. Scientists initially studied ACE-167 for its potential to elucidate mechanisms underlying cholesterol regulation in mitochondria. It is also being studied for its role in various metabolic pathways. Today, it is primarily studied for its effects on:

• Mitochondrial cholesterol transport
• Endocrine biosynthesis models
• Cellular energy metabolism

VDAC1 plays a critical role in mitochondrial permeability and apoptosis.

PeptideSource editorial · Updated Jul 19, 2026