Larazotide

Larazotide acts by modulating tight junctions in the gut epithelium, preventing permeability alterations that can lead to disorders. It is a synthetic peptide derivative, distinct from naturally occurring peptides in the human body. Initial research interest in Larazotide emerged from the need to address intestinal barrier dysfunction, particularly in conditions like celiac disease. Its ability to influence the paracellular pathway has made it a focal point for studies on gastrointestinal health. Today, it is primarily studied for its effects on:

• Celiac disease
• Intestinal permeability
• Gastrointestinal disorders

Researchers are also looking at its potential in treating other autoimmune conditions.

PeptideSource editorial · Updated Jul 18, 2026