MK-677

MK-677, also known as Ibutamoren, is a potent growth hormone secretagogue. It functions by stimulating the ghrelin receptor, which in turn leads to increased secretion of growth hormone. MK-677 first drew attention for its potential in addressing growth hormone deficiencies and related conditions. Unlike endogenous peptides that trigger growth hormone release, MK-677 is synthetic and orally active, making it a convenient option for research. Its unique mechanism and ease of administration have driven extensive research interest in its various applications. Today, it is primarily studied for its effects on:

• Growth hormone deficiency
• Muscle wasting
• Bone density
• Aging
• Sleep improvement

Recent studies have explored its effects on metabolic health and cognitive function.

PeptideSource editorial · Updated Jul 18, 2026