Orexin A

Orexin A, also known as Hypocretin-1, is a neuropeptide produced in the hypothalamus that plays a significant role in regulating wakefulness and appetite. It functions by binding to orexin receptors, which are involved in the modulation of arousal, sleep-wake cycles, and energy homeostasis. Research on Orexin A began with studies exploring its impact on sleep disorders, particularly narcolepsy, as scientists sought to understand its influence on sleep regulation. The peptide quickly garnered interest for its potential effects on enhancing cognitive function and energy levels. Today, it is primarily studied for its effects on:

• Sleep regulation and disorders
• Cognitive enhancement
• Energy balance
• Appetite control

Beyond that, work continues on its broader implications for neurological health.

PeptideSource editorial · Updated Jul 18, 2026