Palmitoyl Tripeptide-38

Palmitoyl Tripeptide-38 acts by stimulating the production of six major components of the skin matrix and dermal-epidermal junction, particularly collagen and hyaluronic acid. This synthetic peptide, also known as Matrixyl 3000, is derived from a combination of palmitic acid and a tripeptide fragment that mimics the naturally occurring peptide sequence in the skin. Early research interest emerged from the need to address skin aging at a molecular level, focusing on enhancing skin repair and rejuvenation processes. Researchers are also looking at its potential effects on skin elasticity and firmness. Today, it is primarily studied for its effects on:

• Enhancing skin hydration
• Reducing the appearance of wrinkles
• Improving skin elasticity

PeptideSource editorial · Updated Jul 18, 2026