PNC-28

PNC-28 is a peptide derived from a segment of the human p53 protein, known for its crucial role in regulating cell growth and apoptosis. This synthetic peptide functions by targeting and disrupting mitochondrial membranes, leading to the induction of cell death in cancerous cells. Research on PNC-28 began with its potential to selectively kill cancer cells while sparing normal cells, sparking interest due to its unique mechanism of action. Today, it is primarily studied for its effects on:

• Cancer cell apoptosis
• Selective cytotoxicity
• Mitochondrial membrane disruption

This peptide's ability to differentiate between healthy and malignant cells has made it a focal point of cancer therapy studies.

PeptideSource editorial · Updated Jul 18, 2026